Bioinspired nanostructured spiderweb for high-efficiency capturing and killing of bacteria

Antibacterial nanoagents with broad-spectrum antibacterial activities have emerged as an evolution of antibiotics. However, their bacteria-capturing capability and bacteria-killing efficiency remain insufficient for commercial implementation. Inspired by the hunting behavior spiders, here, a novel spiderweb-like nanoagent based on silver-adenine nanowires is designed to achieve high-efficiency capture killing bacteria. By virtue initiative functionality, this could effectively attract trap bacteria through electrostatic interaction its reticular morphology feature. Furthermore, synergetic mechanism combining physical membranolysis reactive oxygen species (ROS) release allows such harvest promoted bactericidal activity. Importantly, woundplast employing exhibits superior efficacy against drug-resistant Gram-negative Escherichia coli Gram-positive methicillin-resistant Staphylococcus aureus compared commercially available woundplasts. This work may pave new way rational design generation agents facing future super-bacteria booming.